Molecular control of gonadal differentiation within the chicken embryo

Molecular control of gonadal differentiation within the chicken embryo

Within the embryo that is mammalian two essential ovarian pathways have now been defined. The initial requires the ?-catenin signalling pathway that is canonical. In this path, ovarian signalling molecules R-Spondin 1 (Rspo1) and Wnt-4 activate the ?-catenin pathway when you look at the developing feminine gonad (Fig. 2 ). Rspo1 is presently considered to stimulate Wnt4, and so they then function together to stabilise ?-catenin (Tomizuka et al. 2008 ). Continue reading “Molecular control of gonadal differentiation within the chicken embryo”